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KMID : 0370019940080000067
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Chung-Ang Journal of Pharmacal Sciences
1994 Volume.8 No. 0 p.67 ~ p.71
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Effect of ceramide on the c-myc and c-fms expression in Swei cells
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Abstract
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The effect of ceramide on the expression of protooncongences, c-myc and c-fms, has been investigated in Swei cells. Treatment with a synthetic cell-permeable ceramide(N-acetylsphingosine) caused increase in c-fms mRNA in a time-dependent manner. The induction of c-fms gene was detected at 3 hr and the peak effect occurred at 24 hr after the addition of 6μM of ceramide. The expression of c-myc protooncogene was decreased at 1 hr 30 min in Swei cells. Ceramide also inhibited cell growth in a dose-dependent manner in Swei cells. These results suggested that ceramide in involved in the regulation of cell growth.
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